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The sensation of pain is triggered by the nervous system, usually in response to an injury or illness. The pain sensation hurts, causing discomfort, distress and perhaps agony, depending on its severity.

Pain can be felt in a variety of forms; it can be dull and constant, or short and sharp. Pain may be experienced in one area of the body, such as the back or abdomen, or it can be felt all over, like when your muscles ache during the flu. Pain can be very useful for helping to diagnose a problem. Without pain, trauma may occur without someone even realising it. Alternatively, a medical condition may remain hidden without the associated pain to help identify it. Once the instigating injury or illness has been treated, the pain will usually subside. In these instances, the pain can be classified as being acute.

However, sometimes pain can continue for weeks, months or even years. This is known as chronic pain. Chronic pain can be the result of a long-term condition, such as arthritis or cancer. In other cases, the cause can remain unknown. The most common types of pain include:

  • Back pain – most cases of back pain aren’t caused by anything too serious. In most cases, back pain is caused by minor sprains or injuries. These injuries can be incurred by bending or twisting awkwardly, lifting heavy objects, overstretching, slouching or hunching, and overusing muscles. Some cases of back pain can be the result of a more serious medical condition, such as sciatica, arthritis or a slipped or prolapsed disc. On rare occasions, back pain can be the sign of something more serious, such as a spinal fracture or cancer.
  • Headache – headaches can be divided into two categoriesprimary and secondary. Primary headaches are, in most cases, caused by a dysfunction or an over activity in the pain- sensitive structures in the head. Examples of primary headaches include; migraine, tension headache and cluster headaches. Secondary headaches are a symptom of another condition that stimulates the pain-sensitive nerves in the head. An example of a secondary headache is an alcohol-induced hangover.
  • Joint pain – is the result of damage to the joints, either through disease or injury. A variety of conditions can lead to joint pain, including; osteoarthritis, rheumatoid arthritis, gout, bursitis, sprains, strains and other injuries.
  • Period pain – is the result of muscular contractions of the womb. These contractions constantly pass through the womb, however, they are usually so mild that they pass unnoticed. During menstruation, these contractions can become more vigorous. This is to encourage the wombs lining to shed away as part of the monthly cycle. These more intense contractions can compress the blood vessels in the womb, temporarily cutting off the blood supply. Without blood, the tissues in the womb become deprived of oxygen, which causes them to release chemicals that trigger pain in the body.
  • Muscular pain – also known as myalgia, is often the result of too much stress, tension, or physical activity. However, in some cases, myalgia can be related to a medical condition, such as; viral or bacterial infections, fibromyalgia, thyroid problems, hypokalemia (low potassium), autoimmune disorders, and certain medicines, such as ACE inhibitors.
  • Dental pain – toothache is usually the result of the tooths innermost layer becoming inflamed. This layer is known as the dental pulp and is made up of sensitive nerves and blood vessels. The dental pulp can become inflamed as a result of; tooth decay, receding gums, a cracked tooth, loose or broken fillings, and a periapical abscess. Other conditions that can cause dental pain, without the dental pulp being affected, include; sore and swollen gums, sinusitis, ulcers, periodontal abscess, and injury to the temporomandibular joint, which connects the jaw to the skull. Babies can always experience dental pain when their teeth begin to develop. This is called teething.

If the pain is being caused by an underlying disorder, treating said disorder will also relieve the associated pain. For example, if suffering from a bacterial infection, taking the appropriate course of antibiotics should clear up the infection, which should result in the elimination of the associated pain. If the pain is moderate to severe, it may also be necessary to use analgesics (painkillers), until the underlying cause has been treated.

Analgesics are effective at relieving nociceptive pain but aren’t effective at combating neuropathic pain.

Opioid Analgesics

If suffering from a mild headache or a muscle strain, an over-the-counter pain reliever will usually be enough to ease the pain. However, if the pain is more severe, the doctor may recommend something a lot stronger, such as an opioid analgesic.

Opioid analgesics are the strongest painkillers, which are only available with a valid prescription. They are commonly used after surgery, for broken bones, burns, cancer, and under various other circumstances where the pain is likely to be severe. Opioid analgesics work by binding to the opioid receptors in the brain and spinal cord. This causes a reduction in the pain messages being sent to the brain, thus reducing the feelings of pain. An opioid will usually be administered in gradually increasing dosages. The aim of this method of administration is to achieve the ideal dose, which is when the pain is sufficiently relieved, whilst the side-effects remain tolerable. By taking too high a dose, the side-effects can become too much for the sufferer. Opioid dosages are generally much lower for infants and the elderly.

The most common side-effects that opioid analgesics produced include;

  • Nausea/vomiting
  • Drowsiness
  • Constipation
  • Itching

Usually, these side-effects lessen with time. Opioid analgesics should always be taken with great care, as taking too much can be dangerous. Opioids can also cause addiction – patients who use opioids frequently over long periods, can find themselves dependent on them. For these patients, if treatment were suddenly stopped, they would suffer withdrawal symptoms, which makes it important that their dosage is instead gradually tapered off. Examples of opioid analgesics include:

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